Alpha methyltryptamine (AMT) is a tryptamine (indole ethylamine) derivative, which was developed in the 1960's by Upjohn with the intention for use as an antidepressant. It was used in Russia under the trade name Indopan for the treatment of Bipolar disorder and some form of depression, but currently not being produced because of serious side effects. In the 1990's, alpha-methyltryptamine became regulated as a Schedule I controlled substance in the United States.

Indopan:
https://drugs.ncats.io/drug/BIK35ACJ0Q

AMT is a tryptamine derivative and shares many pharmacological similarities with those of Schedule I hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, psilocybin,and LSD. Since 1999, AMT has become popular among drug abusers for its hallucinogenic like effects. In the 1960s, following extensive clinical studies on AMT as a possible antidepressant drug, the Upjohn Company concluded that AMT was a toxic substance and produces psychosis.

AMT has no currently accepted medical uses in treatment in the United States.

AMT elicits subjective effects including hallucinations. It has an onset of action of about 3 to 4 hours and duration of about 12 to 24 hours, but may produce an extended duration of 2 days in some subjects. AMT can alter sensory perception and judgment and can pose serious health risks to the user and the general public.

AMT is abused for its hallucinogenic effects and is used as substitute for MDMA. It is often administered orally as either powder or capsules. Other routes of administration include smoking and snorting.

DEA (PDF 1 page):
https://www.deadiversion.usdoj.gov/drug_chem_info/amt.pdf

World Health Organization 2014:
Alpha-methyltryptamine (AMT)is a stimulant hallucinogen that has recently been emerging in the club and rave scene. It is part of a class of chemicals called tryptamines,which produce hallucinogenic effects. It produces amphetamine like mood elevating effect and is used as a substitute for MDMA. Lower doses of AMT produce stimulant effects and increasing the dose causes more hallucinogenic effects.

AMT has a slow onset of action of 3 ‐ 4 hours,but an extended duration of 12 ‐ 24 hours although some users have reported effects for 2 days. AMT also diminishes user inhibitions and cause hallucinations, which can result in high risk sexual activity or accidental injury.

Excerpt (PDF 3 pages) https://www.who.int/medicines/areas/quality_safety/4_20_EPR_2.pdf

Street/brand names:
AMT has been sold on its own in powder, tablet or capsule form. It has been sold under different names (for example under the street name of Disco Biscuits), and has been found in at least two different types of unmarked pills.

Appearance:
AMT is an off white or yellowish/orange powder. The consistency can be either clumpy or fine. It is also found in tablet form. These are commonly referred to as pellets to avoid accusations that they are medicinal products. They are small blue pellets typically containing 30mg freebase powder. AMT is also found in freebase form. AMT or 5-IT has been discovered in tablets sold as Ecstasy including pale pink tablets with a cherry logo and white tablets with a Mitsubishi logo. Due to the complications of distinguishing between AMT and 5-IT in analysis it is not confirmed which is the active ingredient in these tablets.

Information Sheet AMT (PDF 7 pages):
http://thedrugswheel.com/drugwatch/AMT_Infosheet_SDF_DrugWatch1_5.pdf

Erowid Experience Vault:
https://erowid.org/experiences/subs/exp_AMT.shtml

DOJ National Drug Intelligence Center Fast Facts (PDF 2 pages):
https://www.justice.gov/archive/ndic/pubs9/9575/9575p.pdf

• A psychedelic, stimulant, and entactogen drug
• Was originally developed as an antidepressant in the 1960s and was used briefly as an antidepressant in Russia under the trade name Indopan before being discontinued.
• Under the trade name Indopan, 5-10 milligrams were used for an antidepressant effect
• With 20 - 30 milligrams, euphoria, empathy, and psychedelic effects become apparent and can last as long as 12 hours
• A dose exceeding 40 mg is generally considered strong
• In rare cases or extreme doses, the duration of effects might exceed 24 hours
• AMT in freebase form is smoked, with doses between and 2 and 5 milligrams

Side effects include anxiety, restlessness, muscle tension, jaw tightness, pupil dilation, tachycardia, headaches, nausea, and vomiting, among other effects that might commonly be attributed to LSD, psilocybin, DMT, and MDMA, such as open-eye visuals, closed eye visuals and an altered state of mind