Methoxyacetyl-fentanyl review:
This isn't a vendor review, just a review with my experience of methoxyacetyl-fentanyl. I recieved a sample of methoxtacetyl-fentanyl. This chemical is EXTREMELY potent and IS NOT to be used by anyone who doesn't know what they are doing. This chemical will easily kill you if extreme precautions aren't taken. The dosages for an opioid-naive individual are as follows. * .5mg (500mcg) - light * 1mg (1000mcg) - normal * 1.5mg-2mg - strong/heavy. About me, I have extensive experience with opioids, have a tolerance, and am also on suboxone, anyone familiar with suboxone knows that it takes a much heavier dose to break through the suboxone. To start off, I took an allergy dose, I weighed out 10mg, and dipped a toothpick to pick up an amount that was about 1/50 of the size of the 10mg pile, so it should have been about 200mcg - 300mcg. WARNING: I DO NOT RECOMMEND THIS, this chemical is way too potent to be eyeballing allergy doses, this chemical should ALWAYS be dosed via volumetric dosing, the ONLY reason I did this is because of my high tolerance and the buprenorphine/nalaxone in my system. After waiting 15minutes with no effects (positive or negative) I went up to 500mcg, waited another 15minutes, still nothing, besides very mild anxiety relief, but that could have been placebo, next I went for 1mg, and after 10 minutes, I noticed EXTREMELY mild depressant activity, still no opioid euphoria, then I decided to try 2mg, after 10minutes this is when I noticed definite opioid activity. So my calculations lead me to believe 4mg is where someone with my tolerance gets definite opioid effects. Again, this DOES NOT mean you should start off with 4mg if you have a tolerance, fentanyl analogues can be extremely unpredictale and dangerous, you can always take more, you can never take less, don't risk dying over chemical research. After monitoring my heart rate, and analyzing my experience for about 10 minutes, I decided to take 2 more milligrams. This is where I noticed powerful euphoria (not overwhelmingly powerful, not nodding out or anything) So 6mg over the course of 45minutes is where I felt the most effects. I don't plan on taking anymore soon, but here are my notes on the effects. * It is a lot more euphoric than most fentanyl analogues I have tried. *. It doesn't make me as tired as other analogues *. It doesn't make me very itchy compared to heroin or other opiates.

Methoxyacetyl-fentanyl review (12 comments):
https://www.reddit.com/r/fentanyl/comments/5vnwj5/methoxyacetylfentanyl_review_xpost_from/

Methoxyacetyl Fentanyl

Duration:
Route	Onset	Duration	After Effects
Tripsit Factsheets
Methoxyacetyl-Fentanyl Basic Information: http://drugs.tripsit.me/methoxyacetyl-fentanyl
Insufflated:	10-20 minutes	10-20 minutes	1-4 hours
Aliases: maf desfluoroocfentanil

World Health Organization 2016:

Substance Identification:
Methoxyacetylfentanyl is a synthetic analogue of the opioid fentanyl. Samples obtained from seizures and from other collections suggest that methoxyacetyl fentanyl has appeared in powders, liquids, and tablets.

Effects on Central Nervous System:
In people using methoxyacetylfentanyl the most serious acute health risk is respiratory depression, which in overdose can lead to respiratory arrest and death.This is consistent with its opioid mechanism of action.

Abuse:
There is evidence that methoxy acetyl fentanyl has been used by injection and by nasal insufflation of powder. A large number of seizures of this substance have been reported in Europe and the United States.A number of deaths have been reported in Europe and the United States in which methoxyacetylfentanyl was detected in post-mortem samples. While other drugs were present in most of these cases, methoxyacetylfentanyl was deemed the cause of death or a major contributor to death in a significant proportion of these. Several countries have controlled methoxyacetylfentanyl in their national legislation.

Recommendation:
Methoxyacetylfentanyl is not known to have any therapeutic uses. The committee considered that methoxyacetylfentanyl is a substance with high abuse liability and dependence potential. It is an opioid agonist that is more potent than morphine and its use has contributed to a large number of deaths in different regions. It has no therapeutic usefulness and it poses a significant risk to public health. The Committee considered that the evidence of its abuse warrants placement under international control.

(PDF page 5 / 22 pages) (41st Expert Committee on Drug Dependence):
https://www.who.int/medicines/access/controlled-substances/Annex_1_41_ECDD_recommendations_NPS_and_medicines_22012019.pdf#page=5

World Health Organization Methoxyacetyl Fentanyl (PDF 25 pages):
https://www.who.int/medicines/access/controlled-substances/Methoxyacetylfentanyl.pdf

EMCDDA - Europol Joint Report 2018:
Methoxyacetylfentanyl belongs to a group of synthetic opioids known as the fentanils. It is closely related to fentanyl, which is controlled under the United Nations Single Convention on Narcotic Drugs, 1961. Data suggests that methoxyacetylfentanyl may be an opioid narcotic analgesic in humans, and, as such, may have an abuse liability and dependence potential; overall, these effects may be broadly comparable to fentanyl. The most serious acute health risk posed by methoxyacetylfentanyl is likely to be respiratory depression, which in overdose is life-threatening. The antidote naloxone should reverse this respiratory depression.

Methoxyacetylfentanyl has been available in the European Union since at least November 2016. It has been detected in 9 Member States and Norway where it has been seized as a powder, liquids, and tablets. The detected quantities are relatively small; however, they should be seen within the context of the high potency that is typical of the fentanils.

Methoxyacetylfentanyl is sold and used as a substitute for illicit opioids and prescription opioids. Similar to other fentanils, serious concerns exist that the substance could be supplied surreptitiously to a range of drug users. Methoxyacetylfentanyl does not appear to have any recognised human or veterinary medical use in the European Union.

Methoxyacetylfentanyl Joint Reports (PDF 16 pages):
https://www.emcdda.europa.eu/system/files/publications/7925/20181015_TDAS18002ENN_PDF.pdf

Methoxyacetyl fentanyl Monograph (PDF 4 pages):
http://www.swgdrug.org/Monographs/methoxyacetyl%20fentanyl%20HCl.pdf

Methoxyacetyl fentanyl (hydrochloride) Safety Data Sheet (PDF 5 pages):
https://www.caymanchem.com/msdss/20782m.pdf

an opioid analgesic that is an analog of fentanyl and has been sold online as a designer drug. Side effects of fentanyl analogs are similar to those of fentanyl. A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week.