Normethadone is a derivate of opioid analgetic methadone, used as component of antitussive drops in Canada. Illicit drug.

Normethadone:
https://drugs.ncats.io/drug/KR2L2A68XL

Antitussive (cough suppressant): This medication is used to treat coughs that have not responded to other treatments. It works by blocking pain signals that are sent out by the brain to various areas of the body and reduces cough by acting in the brain to dull the cough reflex. Note that a cough is a symptom. Before taking a cough suppressant, it is important to assess the underlying cause of the cough.

Antitussive: Cophylac (Normethadone and hydroxyephedrine) is a formulation containing normethadone which is a synthetic opioid and hydroxyehedrine that is a sympathetic stimulant. Cophylac is used primarily as an antitussive (cough suppressant).

Side effects of Cophylac:

• Cardiovascular: Hypotension, Syncope
• Central Nervous System: Ataxia, Dizziness, Drowsiness, Drug Abuse, Drug Dependence, Headache, Insomnia, Neonatal Withdrawal
• Dermatologic: Diaphoresis, Pruritus
• Gastrointestinal: Constipation, Decreased Appetite, Nausea, Vomiting, Xerostomia
• Neuromuscular & Skeletal: Asthenia
• Ophthalmic: Visual Disturbance
• Respiratory: Respiratory Depression

Symptoms And Treatment Of Overdose:
Symptoms: An overdose of 4 mL taken within 4 to 5 hours has produced transient nausea, cold sweat, and tachycardia in one reported case. Should 33% or more of one bottle be ingested, paralysis of the respiratory centre may result. Treatment: Naloxone HCl.

Dosage And Administration:
Adults and children over 14 years, 15 drops twice daily; children 3 to 14 years, 5 to 10 drops twice daily; children under 3 years, 2 to 5 drops twice daily. Drops are dispensed by inverting the drop dispensing bottle. May be taken plain, with sugar or in any beverage, preferably after breakfast and at bedtime. Cophylac Expectorant should not be taken more than twice a day and never on an empty stomach.

How should I use this medication?
For adults and adolescents over 14 years of age, the usual recommended dose is 15 drops twice daily, preferably after breakfast and at bedtime. For children between 6 and 14 years of age , the usual recommended dose is 5 to 10 drops 2 times daily, preferably after breakfast and at bedtime. Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. You should always use the dropper that comes with the bottle of normethadone - hydroxyephedrine. To take the medication, turn the drop-dispensing bottle upside down. This medication can be taken on its own or with some sugar. It can also be added to a drink (e.g., juice); if this is done, make sure you consume all of the drink to ensure you get the full dose of the medication.

What form(s) does this medication come in?
Each mL of sugar-free solution contains 10 mg of normethadone HCl and 20 mg of p-hydroxyephedrine HCl. Nonmedicinal ingredients: citric acid anhydrous, glycerin, lemon oil, methylparaben, and purified water.

Instructions:
This medication is typically used twice a day. Its effects can be felt within 1 hour. This medication may be taken with or without food. Consuming alcohol may intensify the effect of this product. It is therefore advisable to avoid consuming alcohol or alcohol-containing products while taking this medication.

Side effects:
In addition to its desired action, this medication may cause some side effects, notably:

• it may cause constipation - to prevent this, drink plenty of water or juice, and eat more dietary fibre;
• it may cause drowsiness - use caution when driving.

Each person may react differently to a treatment. If you think this medication may be causing side effects (including those described here, or others), talk to your doctor or pharmacist. He or she can help you to determine whether or not the medication is the source of the problem.

Warning:

• This drug has an opioid drug in it. Opioid drugs can put you at risk for addiction, abuse, and misuse. Misuse or abuse of this drug can lead to overdose and death. If you have questions, talk with your doctor.
• You will be watched closely to make sure you do not misuse, abuse, or become addicted to this drug.
• This drug has an opioid drug in it. Severe side effects have happened when opioid drugs were used with benzodiazepines or other drugs that may make you drowsy or slow your actions. This includes slow or troubled breathing and death. Benzodiazepines include drugs like alprazolam, diazepam, and lorazepam. Benzodiazepines may be used to treat many health problems like anxiety, trouble sleeping, or seizures. If you have questions, talk with your doctor.
• Many drugs interact with this drug and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use this drug with all of your drugs.
• Do not take with alcohol or products that have alcohol. Unsafe and sometimes deadly effects may happen.
• Get medical help right away if you feel very sleepy, very dizzy, or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
• This drug may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing.
• The chance of very bad and sometimes deadly breathing problems may be greater when you first start this drug or anytime your dose is raised.
• Even one dose of this drug may be deadly if it is taken by someone else or by accident, especially in children. If this drug is taken by someone else or by accident, get medical help right away.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Using this drug for a long time during pregnancy may lead to withdrawal in the newborn baby. This can be life-threatening. Talk with the doctor.

Precautions:
Before using Normethadone Hydrochloride, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below. Breast feeding, Constipation, Planning to have baby, Pregnant.

Synthetic opioid analgesic and antitussive agent. Has an annual manufacturing quota of 2 grams.