Anadrol is one of those drugs that many people know nothing about their medical uses. It is known more as an illegal anabolic steroid used by bodybuilders and athletes. It is ranked among the most powerful compounds these groups of users use. Oxymetholone is a derivative of dihydrotestosterone (DHT), like some other compounds such as Winstrol and Anavar. Anadrol is a highly anabolic steroid. Its anabolic to androgenic ratio is higher than some other similar compounds. The anabolic potency is more than three times that of testosterone at 320. But the androgenic strength, compared to the male androgen hormone, is significantly lower at 45.

Scientists first described the steroid in papers released in 1959. It was made commercially available by Syntex and Imperial Chemical Industries for medical use in 1961 under the brand name Anapolon. The drug was also released in the same year by Parke-Davis under the name Adroyd. Syntex would release oxymetholone as Anadrol in 1962.

What is Oxymetholone:
In the bodybuilding world, 'oxymetholone' is the chemical profile belonging to many of the big brand anabolic steroids currently on the market, including Anadrol. Oxymetholone is believed to encourage increased testosterone levels, muscle mass and protein synthesis, as well as improved muscle recovery, strength and stamina. By raising red blood cell production in your body, this can ensure the successful delivery of oxygen to your muscles (preventing fatigue and energy losses).

Alongside assisting blood transfusions, folic acid and antibacterial therapy in the treatment of red blood cell deficiency; Oxymetholone has also earned itself a strong reputation within the bodybuilding community. Why? Because of its ability to oxygenate your muscles. You see, when your muscles don't receive enough oxygen, this can lead to tiredness and power drops (not good if you want to benefit from an intense workout). That is why, if you really want to strengthen your workouts - and achieve the muscle gains you crave - your muscles NEED to obtain more oxygen to fuel their muscle recovery, development and growth. And the only way to do that, is to ensure that you've got plenty of red blood cells in the first place to transport all this oxygen.

Oxymetholone can be taken orally - yay no injections - and comes in Oxymetholone 50mg tablets.

Oxymetholone cycle:
Naturally, the Oxymetholone dosage of a bodybuilder will vary to that of someone using it for red blood cell deficiency. During a bulking cycle (2 months on and 1.5 weeks off) you should take 2 capsules of Anadrol a day (with water) about 20 minutes before you have breakfast. This should also be accompanied by a typical bulking diet and a suitable exercise programme (check out our other articles on bulking and diet).

Steroid Pump:
Oxymetholone is an extremely powerful and effective oral steroid. Oxymetholone has a very strong androgenic and intense anabolic effect. The liver is strongly loaded by the active substance oxymetholone, since it is 17-alpha-alkylated. Almost the entire proportion of active ingredients passes through the liver without being destroyed.

Oxymetholone is used in building for building up mass and is an active ingredient which can convert to estrogen in high doses and also has an intense progesterone effect, which also explains the mass increases that can be achieved with this steroid. Increases in the double-digit kilogram range after only a few weeks of use are normal when using Oxymetholone. Although it should be noted that these increases consist mostly of water and fat.

A strict diet and the concomitant use of tamoxifen citrate and mesterolone can significantly reduce water accumulation in the body so that a noticeable increase in firm muscle mass is possible.

Oxymetholone increases the number of red blood cells and allows the muscles to absorb more oxygen. This results in a higher endurance and thus better performance. Bodybuilders report big power reserves on the one hand, but also a pronounced, partially painful "pump", so that they had to finish the individual exercises after only a few repetitions and first had to train another muscle. The cited "steroid pump" manifests itself after the intake of oxymetholone in an extreme form and the athlete experiences a corresponding feeling during his training. The high-level androgenic effect of oxymetholone stimulates the regeneration of the body so that it is unlikely to override. The athlete often has the feeling that he can start again from the beginning hours after a strenuous workout. The training pauses can be massively reduced. Here dangers await the joints and bones, which are not accustomed to this stress. Joint pain due to excessive weight is not a rarity.

Less is More:
On one side of the spectrum, the clinical data does show that the more steroids you use, the more muscle you will gain over the span of a cycle. However, the same studies also reveal a dose-dependent decline in muscle growth response relative to increased drug load. Basically, more works better, but there are diminishing returns the higher your dosages go, and how much muscle you net over the span of your life bodybuilding will likely differ based on how aggressively you approach your mass building phases:

Is 25mg of Anadrol a Good Dose?
I can't say any dose of steroids is a good dose, because they're damaging to your health. However, if you are going to take anadrol 25mg is a much safer dose than 50 or 100mg. When it comes to steroids, knowledgeable bodybuilders know it's important to take it slow and steady. Thus you shouldn't shock your body with a new toxic compound, but instead introduce it slowly so your body becomes accustomed to it. This is extra important when you're dealing with powerful anabolics like anadrol. The 25mg dose achieves this delicate balance perfectly. This is because while it's a small enough dose not to shock your body, 25mg of anadrol daily is still effective enough to deliver great results when cycled for 4-6 weeks.

Reliable studies have ascertained that taking more than 50mg of anadrol daily will reduce your appetite and cravings. This isn't ideal for bulking as calories facilitate more muscle growth. Thus more isn't always better when it comes to your anadrol dose.The 25mg dosage does NOT negatively influence your appetite of cravings. This means you'll be able to consume the right amount of protein and calories, needed to simulate new muscle tissue.

by taking 25mg of anadrol for 4 weeks users can add 15 pounds (if you're new to the compound). This is a pretty hefty increase.

Anadrol Gains:
Anadrol-50 (Oxymetholone) is a steroid I've only used on a couple occasions in the past and for me personally, I didn't like it nearly as much as Dbol. I suppose some people respond better to different compounds than others, but Anadrol was one I just didn't take very well to. My temper got pretty bad on Anadrol and it didn't seem like the strength gains were relative to the side effects on it. But I'm not everybody and there are certainly many people who respond very well to Anadrol. I know they say that when it comes to size and strength that Anadrol is the king, but like I said I felt like I got more out of Dianabol.

When I was using Drol I felt like there was too much going on too quickly to feel right on it. Either that or Anadrol was so liver toxic that I felt kind of ill while using it. I know a lot of guys who have gained up to 30 lbs in just one month on Anadrol-50, but I don't remember gains like that when I used it a long time ago. I wish there was more good things I could say about A-50 but I'm just not a fan of it. I'm more of a slow and steady gains kind of guy, and I'd prefer something my body could handle better and something I didn't feel as lousy on.

Harsh Side Effects:
Anadrol, also known as A-bombs or Oxy's, is predominantly used by bodybuilders in the off-season (when bulking); significantly increasing muscular size and strength.

In bodybuilding, anadrol is considered the most powerful oral steroid on the market.

In the early 1960's, anadrol was widely available for bodybuilders to use for cosmetic purposes. As anadrol's harsh side effects became increasingly well-known, the FDA limited prescriptions of oxymetholone in the mid 1970's. Bodybuilders were now unable to obtain anadrol from their doctor, with it now being predominantly prescribed to patients suffering from anemia.

Anadrol is one of the few steroids that is still FDA-approved for medicinal purposes today, alongside anavar, testosterone and deca durabolin.

Anadrol Benefits:

• Rapid weight gain: Anadrol is quite possibly the best steroid in terms of weight gain, and blowing up a user's muscles fast. This makes it a compound particularly coveted by skinny males who want huge gains.
• Muscle-building: Anadrol will take a bodybuilder's muscle size to a whole new level, with it being over 3x more anabolic than testosterone. Some of this size will be temporary intracellular fluid retention, giving the muscles a constant pumped-look. However, the lean muscle gains on anadrol are still significant, due to the steroid skyrocketing testosterone levels, protein synthesis and increasing nitrogen retention.
• Enhances strength: Anadrol is arguably the greatest steroid in powerlifting and strongman circles. This is due to the sheer weight gain and the huge surge in testosterone.
• Oral form: Anadrol 50 essentially is a 50mg tablet. Thus, no injections are needed to reap the rewards from this steroid.
• Joint support: Anadrol is somewhat healthy for the joints, due to its water-retaining properties. It lubricates the joints, increasing elasticity and decreasing inflammation or/and joint pain. Thus, if a bodybuilder does have joint problems, taking a steroid such as anadrol or deca durabolin may be more preferable than winstrol for example; with the latter expelling water and creating more wear on the joints.
• Fat loss: The reason why anadrol may appear to cause fat gain, is due to water retention. The puffiness and bloating from excess fluid can give the appearance of a higher body fat percentage. As it's a bulking steroid, users are likely to combine anadrol with a high calorie diet, resulting in fat gain and additional water retention. This however is linked to the person's diet and not directly related to anadrol itself. Two studies have concluded that anadrol burns significant amounts of subcutaneous fat, when dosed at 100mg per day

Medical Uses of Oxymetholone:

What is Oxymetholone (Anadrol-50) used for?

• Anemia Associated with Chemotherapy
• Anemia Associated with Chronic Renal Failure
• Aplastic Anemia
• Megaloblastic Anemia
• Pernicious Anemia
• Anemia
• Hemolytic Anemia
• G-6-PD Deficiency
• Thalassemia
• Sickle Cell Anemia
• Thrombotic Thrombocytopenic Purpura
• Hemoglobinopathy
• Hemolytic Uremic Syndrome
• Anemia Associated with Folate Deficiency
• Anemia Associated with Iron Deficiency
• Anemia of Unspecified Nutritional Deficiency
• Autoimmune Hemolytic Anemia
• Anemia Associated with Acute Blood Loss
• Anemia Associated with Vitamin B12 Deficiency
• Pancytopenia
• Pure Red Cell Aplasia

This medication is a synthetic male hormone (androgen or anabolic steroid) used to treat a low red blood cell count (anemia). It works by increasing the amount of the hormone (erythropoietin) involved in the production of red blood cells.Due to the risk of serious, possibly life-threatening side effects, this medication must not be used to improve athletic performance or physical appearance. Oxymetholone does not enhance athletic ability. When used as directed under medical supervision, the risks are minimal.

Oxymetholone (17beta-hydroxy-2-[hydroxymethylene]-17-methyl-5alpha-androstan-3-one) is a 17alpha-alkylated anabolic-androgenic steroid and a synthetic derivative of testosterone. It has been approved by the US Food and Drug Administration for the treatment of anemias caused by deficient red cell production. Acquired aplastic anemia, congenital aplastic anemia, myelofibrosis and the hypoplastic anemias due to the administration of myelotoxic drugs often respond. Drug interactions exist with cimetidine, paroxetine, and haloperidol, but are not expected with indinavir, ritonavir, clarithromycin, or itraconazole.

Oxymetholone:
https://drugs.ncats.io/drug/L76T0ZCA8K

Prescribed for:

What Conditions does it Treat?

• Anemia due to depressed bone marrow
• Diamond Blackfan anemia
• Low blood counts due to bone marrow failure

Uses:
This medication is a synthetic male hormone (androgen or anabolic steroid) used to treat a low red blood cell count (anemia). It works by increasing the amount of the hormone (erythropoietin) involved in the production of red blood cells.

Before using:
Tell your doctor or pharmacist your medical history, especially of:

• Kidney disease
• Liver disease
• Heart disease (e.g., congestive heart failure, coronary artery disease)
• Swelling (edema, fluid retention)
• Enlarged prostate
• Diabetes.

Precautions:
Before using this medicine, consult your doctor or pharmacist if you have:

• Breast cancer (males)
• Breast cancer with high blood calcium levels (females)
• Prostate cancer
• Severe kidney disease
• Severe liver disease

If you have diabetes, oxymetholone may increase your blood sugar level. Check your blood (or urine) glucose level frequently, as directed by your doctor and promptly report any abnormal results. Your diabetes medicines may need to be adjusted.

WARNINGS:

This medication may rarely cause serious, sometimes life-threatening liver problems including cysts, tumors, or liver failure. Tell your doctor right away if you have dark urine, yellowing eyes or skin, persistent nausea/vomiting, stomach/abdominal pain, or unusual fatigue.

In addition, this medication may affect your cholesterol level and increase your risk of heart disease (atherosclerosis) or blood vessel problems.

Oxymetholone Tablet:
https://www.webmd.com/drugs/2/drug-5036/oxymetholone-oral/details

Anadrol-50 (oxymetholone)

Maximum Dosage:
Prescribers Digital Reference
Anadrol-50 - Drug Summary: https://www.pdr.net/drug-summary/Anadrol-50-oxymetholone-3444
Adults:	5 mg/kg/day PO.
Geriatric:	5 mg/kg/day PO.
Adolescents:	5 mg/kg/day PO.
Children:	5 mg/kg/day PO.
Infants:	Safety and efficacy have not been established.
Neonates:	Safety and efficacy have not been established.

Anadrol (oxymetholone) (Rx)

Black Box Warnings:
Anadrol (oxymetholone) (Rx): https://reference.medscape.com/drug/anadrol-50-oxymetholone-342785
Peliosis Hepatis Peliosis hepatitis has been reported w/ androgenic anabolic steroid therapy In this condition, the liver & sometimes splenic tissue is replaced w/ blood-filled cysts These cysts sometimes present with minimal hepatic dysfunction but have been associated with liver failure Often not detected until life-threatening liver failure or intra-abdominal hemorrhage develops Discontinuing an anabolic steroid usually results in complete disappearance of lesions Liver Cell Tumors Liver cell tumors have been reported Typically, these tumors are benign & androgen-dependent, but fatal malignant tumors have been reported Discontinuing anabolic steroids often result in regression or arrested progression of tumor Important to recognize that hepatic tumors associated w/ androgens or anabolic steroids are much more vascular than other hepatic tumors & may be silent until life-threatening intra-abdominal hemorrhage develops Blood Lipid Changes May cause blood lipid changes associated w/ increased risk of atherosclerosis Lipid changes include decreased HDL & sometimes increased LDL; changes may be very marked & could have serious impact on risk for atherosclerosis & coronary artery disease

What is the most important information I should know about oxymetholone?
You should not use this medicine if you have:

• Severe liver disease
• Kidney disease
• Prostate cancer
• Male breast cancer
• Female breast cancer with high levels of calcium in the blood
• Pregnancy

Do not use oxymetholone if you are pregnant.

Long-term use of oxymetholone can cause liver tumors or blood-filled cysts in your liver or spleen. Call your doctor at once if you have:

• Upper stomach pain
• Loss of appetite
• Dark urine
• Clay-colored stools
• Jaundice (yellowing of the skin or eyes)
• Rapid weight gain (especially in your face and midsection).

Oxymetholone Brand: Anadrol-50:
https://www.uofmhealth.org/health-library/d04295a1

Anadrol-50 (oxymetholone)

Side Effects:
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
RxList
Anadrol-50 (oxymetholone): https://www.rxlist.com/anadrol-50-drug/patient-images-side-effects.htm
Long-term use of oxymetholone can cause liver tumors or blood-filled cysts in your liver or spleen.
Call your doctor at once if you have: nausea, upper stomach pain rapid weight gain, especially in your face and midsection loss of appetite, dark urine, clay-colored stools jaundice (yellowing of the skin or eyes)
Also call your doctor at once if you have: painful or difficult urination increased interest in sex, painful or ongoing erection of the penis loss of interest in sex, impotence, trouble having an orgasm, decreased amount of semen when you ejaculate easy bruising or bleeding (nosebleeds, bleeding gums), any bleeding that will not stop painful swelling in your breasts changes in skin color shortness of breath (even with mild exertion), swelling in your hands or feet
Women receiving oxymetholone may develop male features, which could be irreversible if treatment is continued. If you are a woman taking oxymetholone, tell your doctor right away if you have: hoarse or deepened voice increased facial hair, hair growth on the chest male pattern baldness enlarged clitoris changes in your menstrual periods increased or decreased interest in sex
Common side effects in both men and women may include: acne male pattern baldness breast swelling or tenderness (in men or women) feeling restless or excited sleep problems (insomnia) nausea, vomiting, diarrhea
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Important Information:
You should not use oxymetholone if you have severe liver or kidney disease, prostate cancer, male breast cancer, or female breast cancer with high levels of calcium in the blood.

Do not use oxymetholone if you are pregnant.

Long-term use of oxymetholone can cause liver tumors or blood-filled cysts in your liver or spleen. Call your doctor at once if you have upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), or rapid weight gain (especially in your face and midsection).

Interactions:

Drug Interactions (73) Alcohol/Food Interactions (1) Disease Interactions (10)

What other drugs will affect Oxymetholone?
Other drugs may interact with oxymetholone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

A total of 73 drugs are known to interact with Oxymetholone.

• 9 major drug interactions
  • anisindione
  • carfilzomib
  • dicumarol
  • leflunomide
  • lomitapide
  • mipomersen
  • pexidartinib
  • teriflunomide
  • warfarin
• 64 moderate drug interactions

Oxymetholone Information:
https://www.drugs.com/mtm/oxymetholone.html

Onset of Action:
Response is not often immediate; a minimum trial of 3 to 6 months is recommended.

Labeled Indications:
Anemia: Treatment of anemias caused by deficient red cell production. Note: Androgen therapy (eg, oxymetholone) is generally not appropriate for the treatment of anemias except in certain rare situations (eg, Fanconi anemia).

Alternate Names:
OXYMETHOLONE, HMD, ANADROL, OXIMETHOLONE, ANADROL-50, ANAPOLON 50, CI-406, OXYMETHOLON, 17B-HYDROXY-2-HYDROXYMETHYLIDENE-17A-METHYL-3-ANDROSTANONE, OXYMETHOLONE, OXYMETHOLONUM, OXIMETOLONA

Mephobarbital Drug Record:
http://www.dgidb.org/drugs/MEPHOBARBITAL#_summary

Side effects of oxymetholone include increased sexual desire as well as symptoms of masculinization like acne, increased hair growth, and voice changes. It can also cause liver damage. It has strong anabolic effects and weak androgenic effects. Oxymetholone was first described in 1959 and was introduced for medical use by 1961. It is used mostly in the United States. In addition to its medical use, oxymetholone is used to improve physique and performance. The drug is a controlled substance in many countries and so non-medical use is generally illicit.

The primary clinical applications of oxymetholone include treatment of anemia and osteoporosis, as well as stimulating muscle growth in malnourished or underdeveloped patients. However, in the United States, the only remaining FDA-approved indication is the treatment of anemia. Long term use of the drug can cause a variety of serious ailments, including hepatitis, liver cancer, and cirrhosis; therefore periodic liver function tests are recommended for those taking oxymetholone.