Phenadoxone hydrochloride is one of some forty amino-ketones and amino-esters related to amidone. The compound is a very potent analgesic for the rat; by the subcutaneous route it is more active than either morphine or amidone. In spite of this its acute toxicity to mice is lower than that of amidone and its therapeutic index is therefore correspondingly higher, giving a wider margin of safety. Side effects in dogs, such as narcosis, sedation, and general depression, were much less with phenadoxone than with amidone or morphine. Nausea and vomiting did not occur after phenadoxone in non-tolerant dogs. Clinical results show that for relieving certain types of pain in human subjects it is a potent analgesic that compares favorably with morphine and amidone. At therapeutic dose levels undesirable pharmacological effects, such as cardiac depression and vasomotor disturbance, are absent, and it is only at extremely high dose levels that untoward effects occur. However, the drug has a strong respiratory depressant action when given in high doses; it should be used with special caution if injected intravenously.

Phenadoxone:
https://drugs.ncats.io/drug/375W3TA42N

Synonyms:

• Phenadoxone
• Heptazone
• Morphodone
• Phenodoxone
• Phenadoxone Hydrochloride
• Phenadoxone HCl

Phenadoxone:
https://drugcentral.org/drugcard/3435

An opioid analgesic. Invented in Germany in 1947. Phenadoxone is generally considered to be a strong opioid analgesic and is regulated in much the same way as morphine where it is used. The usual starting dose is 10 - 20 mg and it has a duration of analgesic effect of 1 to 4 hours. Phenadoxone is not used at this time for purposes other than pain relief.

It is one of a handful of useful synthetic analgesics which were used in the United States for various lengths of time in the 20 or so years after the end of the Second World War but which were withdrawn from the market for various or no known reason and which now are mostly in Schedule I of the United States' Controlled Substances Act of 1970

Phenadoxone has a had a zero annual manufacturing quota under the Controlled Substances Act 1970. It is, however, used as a legitimate medication in other countries and consumption is increasing worldwide. Phenadoxone is most used at the current time in Denmark and various countries in eastern Europe.